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Cobra rad 480i vs 45012/31/2023 ![]() Now that you know a bit about radar detectors and their benefits, it’s time to dive into the details of each product. ![]() ![]() Additionally, some detectors even have GPS capabilities, allowing them to provide alerts for fixed red light and speed cameras as well. With the ability to detect and alert you to radar and laser signals, these devices give you ample time to adjust your speed and stay within legal limits. Not only can it help you avoid speeding tickets and save you money, but it can also provide a heightened sense of security on the road. Owning a radar detector has many benefits. Nowadays, they offer a wide range of features and functionalities that make them a must-have for any conscientious driver. However, as technology advanced, so did these detectors. Originally, they were simple devices that alerted drivers to the presence of radar signals emitted by law enforcement officers. Radar detectors have come a long way since their introduction in the 1970s. These devices are designed to help you detect and avoid radar and laser speed traps, giving you the peace of mind you deserve while driving. Are you tired of getting caught by speed traps or constantly worrying about getting a speeding ticket? Well, you’re in luck because we’ve got just the solution for you! In this article, we’ll be reviewing and comparing of two of the most well known brands of radar detectors on the market.
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Sau đó nhấn chọn ảnh hoặc thư mục chứa ảnh. Ứng dụng này cũng cung cấp các bộ lọc khác nhau mà bạn có thể áp dụng để cho ra những kết quả thú vị. Let us help you start your creative journey with Evoto. ![]() Evoto is a next-generation photo retouching tool that uses advanced artificial intelligence technologies to automate and enhance various aspects of photo editing. ![]() Evoto also allows for batch image editing, which can detect EVOTO, AI-powered Photo Editor Experience the future of photo editing with Evoto, a next-generation AI photo editor that simplifies your workflow and unleashes your creativity. The best AI photo editor 2023 overall Platform: Windows, macOS | Free trial: No | Cost: $10/m (Yearly) or Meet Evoto, a new AI-powered image editor By Julie Powell 0 There is a big hype about AI image editing software at the moment. Evoto, the next generation photo editor that frees you from tedious work, is set up to process thousands of photos at x10x speed with exceptional quality and help you turn your imagination into realistic. It can pinpoint the difference between real image detail and noise with amazing accuracy. Next generation AI photo retouch tool launches with affordable credit based pricing. Colorize B&W photos to make it come to life again. Evoto AI cung cấp một giải pháp toàn diện để xử lý và chỉnh sửa hình ảnh, tận dụng sức mạnh của AI để tạo ra kết quả chuyên nghiệp, chất lượng cao. Trình giả lập Android là phần mềm mô phỏng hệ thống điện Evoto, trình chỉnh sửa ảnh thế hệ tiếp theo giải thoát bạn khỏi công việc tẻ nhạt, được thiết lập để bạn xử lý hàng nghìn bức ảnh ở tốc độ x10 lần với chất lượng vượt trội và giúp bạn biến trí tưởng tượng của mình thành The second big name in AI photo editing software is Topaz. Topaz Studio 2 is a layer-based editor, much like Adobe Photoshop. ![]() Download Phần mềm AI retouch ảnh Evoto Download Adobe Free và cài Camera Raw 14. Remove unwanted objects, people, watermarks. Click on "Download Free Trial" and follow the instructions to install Evoto AI on your computer 3. Evoto ai crack mac free download, Has anyone been using it in thei Evoto ai crack mac free download, Has anyone been using it in their workflow and/or has opinions? THANK YOU! It features powerful portrait retouching tools, advanced color editing tools, and smart background adjustments.
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State of nh liquor store12/31/2023 ![]() There are also no restrictions on the hours or days of the week when alcohol can be sold. And no requirements for license holders to be residents of the state. ![]() New Hampshire’s alcohol laws are some of the most permissive in the United States. ![]() New Hampshire does not have a state liquor board or commission that regulates the sale of alcohol.Īlcohol regulators in New Hampshire include the Bureau of Enforcement and Licensing within the Division of State Police, which is responsible for issuing retail licenses and investigating license violations the Liquor Commission, which is responsible for issuing wholesale licenses and local police and municipalities, which are responsible for enforcing liquor laws. New Hampshire is not a liquor control state. New Hampshire law states that bars, restaurants and hotels may serve alcohol, but they can only sell it to patrons in sealed containers. Beer and wine can also be purchased at some grocery stores, however most grocery stores can only sell beer.Ī few may sell wine, but these are also not permitted at gas stations. New Hampshire law states that the sale of alcoholic beverages must be done through state-approved liquor stores. No, you cannot buy alcohol at a gas station in New Hampshire. Is there tax on liquor in NH? Can you buy alcohol at a gas station in NH?.Are New Hampshire liquor stores open on Sunday?.Does New Hampshire have state liquor stores?.Can liquor be shipped to New Hampshire?.Do they sell beer at gas stations in New Hampshire?.What state has the strictest liquor laws?.Does Walmart sell liquor in New Hampshire?.Is New Hampshire a liquor control state?.Can you buy alcohol at a gas station in NH?.It is important to note that it is illegal for anyone in New Hampshire to provide alcohol to minors. In many cases, this will occur at bars and restaurants, where customers may purchase beer and wine by the glass. All purchases require valid proof of age, and carrying containers of large sizes may also be subject to limits, depending on the store.Īdditionally, it is important to note that in New Hampshire, any person 21 years of age or older may purchase alcohol from another person of legal age. In order to purchase beer with an alcohol content higher than 8% in New Hampshire, customers should visit a state-run liquor store. Most stores allow customers to purchase alcoholic beverages on the premises, though some may require customers to provide valid proof of age before they can purchase alcoholic beverages. These stores are regulated and owned by the New Hampshire Liquor Commission.Īdditionally, wine and beer may be sold in grocery stores and convenience stores in New Hampshire. In New Hampshire, any person 21 years of age or older can purchase beer, wine, or any other alcoholic beverage (except for grain alcohol, which is only available in state-run liquor stores) from an ABC store. In the state of New Hampshire, the purchase of all alcoholic beverages is regulated by the New Hampshire Liquor Commission.
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System shock remake demo dowload12/31/2023 ![]() (There was also a System Shock 3 launched in 2015, at Looking Glass veteran Warren Spector's OtherSide Entertainment, but that died in 2019.) That's why this fully playable first level, and a seemingly firm March 2023 release date, arriving during Steam's Next Fest demo week, caught many of those following along flat-footed. Five years ago, the Kickstarter project launched by those events scaled out of control, and there was a reboot of the reboot. It involves a Guatemalan rainstorm, a Michigan insurance company, and a French developer with mysterious access to long-forgotten source code. The full story behind this new version of System Shock starts more than a decade ago. How the team handled the bright colors and organic materials of later levels remains to be seen. ![]() Your mind is still meant to fill in some of the gaps of how this space station worked, how people lived, and what it was like when things went terribly wrong. Given thousands more pixels to work with than Looking Glass had, Nightdive has given the first level more color, and far more shadow and light, but not an excess of detail. I heard back that it was "a deliberate design choice." Knowing this, I played a bit more, and the visuals, taken as a kind of knowing throwback, melded a bit more in my mind. ![]() Were the somewhat granular textures a design choice to evoke the original? Consideration for gamers who may not have a top-of-the-line GPU? The nature of working outside AAA development? Some or all of these? I asked Nightdive about this through its marketing team. At the same time, with the graphics maxed out, the game positively hummed along at about 70 frames per second. I'm playing on a budget-focused Nvidia RTX 3050, but even with every graphic setting turned up to "High" or "Ultra," and the resolution set to 4K, it looked about the same. I wasn't expecting a modern AAA shooter, but the rough pixel edges on some objects and textures caught my eye. Enemies perpetually respawning in areas you've already visited might make sense narratively, but it's a mechanic I might have left behind. The melee combat feels just as stiff and non-kinetic as it did in the mid-1990s, which is not a good thing. But I've also noticed some things that left me wondering if there's more to be fixed up in the finished product. So I certainly enjoyed seeing familiar faces: the grungy mutants, the Picard-as-Borg-like cyborg drones, the trash-can-looking bots that flail their arms at you. All that to say: I'm a fairly soft target. I backed Nightdive's Kickstarter for the game in 2016, when it was expected to arrive by the end of 2017. Getting it to run on my dad's Gateway office computer was a big part of my computer education. You can still spend far too much time meticulously organizing your inventory and collecting scrap for junk credits, while supposedly in the midst of a humanity-endangering crisis.įor context, and disclosure, I played the original extensively in the era when Looking Glass still existed. But the beats of the story, the puzzles and enemies and traps, the very core of the innovative, quirky game is still there. There are some new conveniences, like an entirely overhauled interface with better shortcuts for secondary items, like grenades and stim patches. ![]() And, of course, you can play the game on Steam, GOG, or Epic, rather than having to find an ancient CD-ROM. You can blast and pipe-bash enemies, but they aren't Wolfenstein-era 2D sprites anymore. You can punch 0451 into the medical storage locker like it's 1994 again, but this time at modern resolutions and frame rates, using far more comfortable controls, even a gamepad. If you played and loved the original, this demo, and likely the full game, is almost certainly worth your while. Having spent a couple hours in the first level, I'm certainly impressed but curious about some of the decisions and focus areas. I've been waiting to revisit Citadel Station and its malevolent AI since the project's announcement nearly seven years ago. Nobody was expecting to see a PC demo for the System Shock remake this week, least of all me. Enlarge / Dark corridors, cyberpunk lighting, low ammo, mutated humanoids: same as it ever was.
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Java for loop remove from list12/31/2023 ![]() Using ArrayList.remove() method is the fastest way for removing an element from the ArrayList. ("\nAfter removing the element the size of the ArrayList is: " + cities.size()) Īll of the above-discussed methods are used for different scenarios. Removing elements which are start with B using removeIf() methodĬities.removeIf(n -> (n.charAt(0) = 'B')) ("The list of the size is: " + cities.size()) Let's take an example to understand how the removeIf() method is used. We pass the predicate filter to that method as an argument. If we want to remove an element from the ArrayList which satisfy the predicate filter, the removeIf() method is best suited for this case. ("\nAfter removing the element the size of the ArrayList is: " + numbers.size()) Removing elements greater than 10 using remove() method ("The list of the size is: " + numbers.size()) creating an ArrayList having default size 10 Let's take an example to understand how the Iterator.remove() method is used. The Iterator class removes elements properly while iterating the ArrayList. When we use the remove() method while iterating the elements, it throws the ConcurrentModificationException. It is not so helpful in case when iterating over elements. The Iterator.remove() method is another way of removing an element from an ArrayList. ![]() ("\nAfter removing the element the size of the ArrayList is: " + arr.size()) Removing the specified element from ArrayList Showing all the elements in the ArrayList ("The list of the size is: " + arr.size()) By traversing the list from high index to low index, you can safely delete items in a for loop. creating an ArrayList having default size 5 Let's take an example to understand how the remove() method is used. The remove(int index) method accepts the index of the object to be removed, and the remove(Object obj) method accepts the object to be removed. It also provides the two overloaded methods, i.e., remove(int index) and remove(Object obj). Using the remove() method of the ArrayList class is the fastest way of deleting or removing the element from the ArrayList. yourList instance.getStringsWithoutEqualLength (someLength, yourList) You have effectively removed the longer elements and done it faster than if you had used an Iterator. Let's understand all these three ways, one by one. If what you are attempting to do is remove the elements from lijst, then just reassign the returned list to it. However, there is more than one way of removing an element from the ArrayList that are as follows:Īll these three ways are best in their own, and can be used in some different scenario. Adding and removing an element from the ArrayList is very easy by using its built-in methods add() and remove(). The ArrayList class is available in the Java.util package and extends the List interface. ![]() Next → ← prev Remove an Element from ArrayList in JavaĪrrayList is similar to the array whose size can be modified.
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Hitman bodyguard 212/31/2023 ![]() We refine our estimates from week to week as more data becomes available. Il fait suite à Hitman and Bodyguard, du même réalisateur, sorti en 2017. The consumer spending estimate is based on the average sales price for the title in the retailers we survey. Hitman & Bodyguard 2 ou La Femme de mon meilleur ennemi 1 au Québec (Hitmans Wifes Bodyguard), est un film daction multi-nationalité réalisé par Patrick Hughes, sorti en 2021. The market share is converted into a weekly sales estimate based on industry reports on the overall size of the market, including reports published in Media Play News.įor example, if our weekly retail survey estimates that a particular title sold 1% of all units that week, and the industry reports sales of 1,500,000 units in total, we will estimate 15,000 units were sold of that title. Our DVD and Blu-ray sales estimates are based on weekly retail surveys, which we use to build a weekly market share estimate for each title we are tracking. International Cumulative Box Office Records Millennium Films, Lionsgate, Nu Boyana, Campbell Grobman Films, Film i Vast, Filmgate Films R for strong bloody violence throughout, pervasive language, and some sexual content.Īction Comedy, Retirement, Out of Retirement July 22nd, 2021 by Lionsgate Home Entertainment June 11th, 2021 (Wide), released as Duro de cuidar 2 ( Mexico) ![]() See the Box Office tab (Domestic) and International tab (International and Worldwide) for more Cumulative Box Office Records.Īmazon EST, Amazon 4K UHD EST, Amazon VOD/EST, Amazon 4K UHD VOD/EST Latest Ranking on Cumulative Box Office ListsĪll Time Domestic Box Office (Rank 2,301-2,400)Īll Time International Box Office (Rank 2,701-2,800)Īll Time Worldwide Box Office (Rank 2,401-2,500)Īll Time Domestic Box Office for Comedy Movies (Rank 401-500)Īll Time International Box Office for Comedy Movies (Rank 301-400)Īll Time Worldwide Box Office for Comedy Movies (Rank 301-400)Īll Time Domestic Box Office for R Movies (Rank 701-800)Īll Time International Box Office for R Movies (Rank 701-800)Īll Time Worldwide Box Office for R Movies (Rank 701-800) theaters, 3.9 weeks average run per theater $70,000,000 (worldwide box office is 1.0 times production budget)ģ,331 opening theaters/3,361 max. Joining in the fun and deadly mayhem is Morgan Freeman as… well, you’ll have to see.ģ.34 (domestic box office/biggest weekend) Jackson (as high-level assassin Darius Kincaid), and Salma Hayek (as Kincaid's wife, Sonia). It re-teams Ryan Reynolds (as uptight, safety-first bodyguard Michael Bryce, who's still trying to regain his Triple-A certification), Samuel L. As Bryce is driven over the edge by his two most dangerous protectees, the trio get in over their heads in a global plot and soon find that they are all that stand between Europe and a vengeful and powerful madman. Parents need to know that the action comedy The Hitman's Wife's Bodyguard is the sequel to The Hitman's Bodyguard. Still unlicensed and under scrutiny, Bryce is forced into action by Darius’s even more volatile wife, the infamous international con artist Sonia Kincaid. Hughes also said the biggest difference from the first film is that they embraced the comedy elements from the get-go.The world’s most lethal odd couple-bodyguard Michael Bryce and hitman Darius Kincaid-are back on another life-threatening mission. One of the world's top bodyguards gets a new client, a world class hitman who must testify at the International Criminal Court. ![]() With Elodie Yung, Ryan Reynolds, Tsuwayuki Saotome, Roy Hill. Well, where do I go from there? Like, what’s your problem?” The Hitman's Bodyguard: Directed by Patrick Hughes. So, it’s about the internal suffering, so that’s why I felt like you just couldn’t be., Because if we came to part two and he’s in a loving relationship with a beautiful woman that he doesn’t deserve, cause clearly she’s too good for him, then I’d be like, well, I’ve got no story to tell. It’s like, really? Well, you’re still going to be an empty sack of shit inside because that’s who you are as a human being. So he’s searching for what he thinks will make him happy, and what he thinks will make him happy is validation and success and a triple-A rating, and getting his career back. Because it’s the want versus need, and this goes back to mythology, but it’s like, whatever he wants is actually not the right thing that he needs. He needs to want, and whatever he wants, he’s never going to get. “So if he’s found true love, then my movie’s over. “Because Michael Bryce is a suffering fool, so whatever he wants, he can’t have,” said Hughes. When asked why Yung’s character of Amelia wasn’t in the sequel, and the romantic-comedy elements involving Bryce were dropped, director Patrick Hughes had a simple answer.
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Soothing rain sounds for sleep12/30/2023 The popularity of storm sounds Sounds for Sleeping can be attributed to its ability to mask unwanted background noise, such as traffic or conversation, and create a more peaceful environment. ![]() Storm sounds Sounds for Sleeping is often used as a way to block out other sounds and promote relaxation or sleep. The popularity of thunderstorm can be attributed to its ability to mask unwanted background noise, such as traffic or conversation, and create a more peaceful environment. ![]() Thunderstorm is often used as a way to block out other sounds and promote relaxation or sleep. The popularity of storm can be attributed to its ability to mask unwanted background noise, such as traffic or conversation, and create a more peaceful environment. Storm is often used as a way to block out other sounds and promote relaxation or sleep. The popularity of rumbling storm can be attributed to its ability to mask unwanted background noise, such as traffic or conversation, and create a more peaceful environment.Īll video and audio on the channel are created by "Sleepy Sound" ![]() Keep going.Rumbling storm is often used as a way to block out other sounds and promote relaxation or sleep. I want you to know that you are appreciated. Good night for France JW.org Comment by ˚ᰔ Kai ᰔ˚ Night from the USA I hope you get nightmares Comment by Arun S Good night from Oklahoma Comment by ୭ □ ✧ ˚□□★□□□. Goodnight from London Comment by User 564119629 Goodnight from Wales Comment by old magneton □ Perfect Rain Sounds for Sleep or Studying (75 Minutes) □ The melodies in this track are so enchanting and beautiful. □ Perfect Rain Sounds for Sleep or Studying (75 Minutes) □ This song has such a great rhythm, it's impossible to resist. My favorite part is when it rains Comment by Patricia □ Perfect Rain Sounds for Sleep or Studying (75 Minutes) □ The melody on this song is so infectious, it stays with you long after it ends. Any reproduction or republication of all or part of this text/visual/audio is prohibited. If you have significant difficulty sleeping on a regular basis, experience fitful/restless sleep, or feel tired during the day, please consult your physician. The sounds provided by this Youtube channel are for entertainment purposes only and are not a treatment for sleep disorders or tinnitus. If you have difficulty hearing or hear ringing in your ears, please immediately discontinue listening to the white noise sounds and consult an audiologist or your physician. Please do not place speakers right next to a baby’s ears. When playing one of our videos, if you cannot have a conversation over the sound without raising your voice, the sound may be too loud for your ears. relaxing-white-noise/sets/rainĭISCLAIMER: Remember that loud sounds can potentially damage your hearing. Clear your mind and be your best.Ĭheck out our Rain Sounds Playlist for more storm sounds: Not sure how you'll use this sound, but I'm betting it will help you get results. Or maybe it will help you perfect your mime routine. It's a perfect storm out there of steady rainfall that will help you fall asleep or study.
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Graphic organizer template word12/30/2023 ![]() The primary purpose of the brainstorming chart is to make the learners think more about a certain topic. The main idea in this example is the Squirrel, and the sub-ideas are written on the other boxes surrounding it. The learners use the brainstorming chart to put sub-ideas to the main idea. You can use this graphic organizer to put the details of the movie you watched in a sequence, from beginning to end. Another example is when you are watching movies. It is commonly used when trying to summarize the whole story. This graphic organizer example can be seen in school. This example only shows you can tell a story using a graphic organizer. It shows every moment of a person’s life in sequence. Biography TimelineĪs you can see in the example, it is a timeline graphic organizer. If you want to visualize a team inside a company, you can use the organizational chart template and start inserting the name of the people with their position. Under them are the managers, supervisors, and so on, in hierarchical order. The sections at the top of the organizational chart are for the CEO, CFO, Head, or someone with a higher position. ![]() It can help visually organize the people's positions in a particular organization. An organizational chart template is commonly used for internal company purposes. Organizational Chart Graphic Organizer TemplateĪn organizational chart is more about the position or hierarchy. You can use this template if you want to compare two particular concepts. The circles on the sides are their differences. The two first-stemmed circles show the similarities between the topic. The two central circles in an idea web are about the main idea. It shows the differences and similarities between a specific topic or concept. It is also known as a comparison organizer. The idea web graphic organizer template is a combination of two spider maps. It is perfect for taking notes while researching or obtaining an idea of the bigger picture. Moreover, idea wheels are suitable for brainstorming and organizing data about a topic. Then, it is explained inside the same circle. Also, ideas are added around the main idea in sections. The main purpose of an idea wheel is to arrange data hierarchically or in sequence. ![]() It is a sectioned larger circle or connected bubbles. Around the circle, there can be other circles or shapes. The center part of the chart is the main idea or topic being studied. This graphic organizer template is suitable for collaborating, brainstorming, and organizing ideas. You can also let others edit your output. You can also click the Share button to get and share the link with other users. Then, click the Save option to save it to your MindOnMap account. Click the Export button to save the graphic organizer to various file formats. If you want to create a graphic organizer using MindOnMap, use the basic steps below.Īfter creating a graphic organizer, you can proceed with the saving process. The tool is available to all web platforms, including Google, Chrome, Edge, and more. It includes PNG, JPG, SVG, DOC, PDF, and more. Additionally, the tool can let you export your final graphic organizer with various output formats. It means that even if you remove the tool accidentally, the output won’t get deleted. ![]() While creating a graphic organizer, the tool can save your work automatically. This way, you can insert all the information you need for your graphic organizer.įurthermore, it has a fantastic feature you can enjoy. Moreover, if you don’t want to start from scratch, use this tool's free editable graphic organizer template. You can also use free themes to make the output lively and attractive. You can use shapes, designs, font styles, colors, and more. When creating a graphic organizer, MindOnMap can offer everything you need. Also, it has an intuitive interface, making it perfect and helpful for non-professional users. The online tool offers simple steps to follow during the creation process. It doesn’t matter if you are a non-professional user. With the help of this graphic organizer maker, you can start creating your graphic organizer. The ultimate tool to use for creating a graphic organizer is MindOnMap. Fortunately, in this part, we will give the answer you want. You need to find a tool first when creating. Outstanding Graphic Organizer Toolįor a beginner, it is challenging to create a graphic organizer. FAQs about Graphic Organizer Template and Example So, do you want to see the templates, examples, and methods immediately? Read the article right now. Also, we will introduce a remarkable tool for creating a graphic organizer. In addition, if you want to create your graphic organizer, we will provide numerous templates you can use. We will give you different graphic organizer templates and examples so that you will get an idea about its appearance. Don’t you have an idea what a graphic organizer looks like? In that case, there is a reason for you to read this article.
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Pca tinted sunscreen12/30/2023 ![]() ![]() He says that mineral sunscreens (also known as physical blockers) use the natural minerals zinc oxide or titanium oxide to reflect the sun's rays, and that they run a low risk of irritation, which is why they're often so well-tolerated by people with sensitive or reaction-prone skin.Ĭhemical sunscreens are your other option, but unlike physical sunscreens that act as a shield to deflect UV rays, chemical sunscreens absorb (and then convert) UV rays as they enter your skin. If you have sensitive skin, mineral sunscreens are preferable, advises dermatologist Dr. They all offer broad-spectrum sun protection (which means they'll protect your skin from UVA and UVB rays) and have an SPF of at least 30, as per the American Academy of Dermatology's recommendation.īut before you get to shopping, some expert sunscreen tips: And who better to help you find one than a dermatologist? Ahead, you'll find seven of the best dermatologist-recommended sunscreens, according to medical experts in the skin care field. The most important thing about sunscreen is that you wear it everyday.
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Causes of fixed dilated pupil12/30/2023 ![]() Oculomotor (third) nerve palsy varies in presentation and etiology. Adie pupil may involve an orbital process, while bilateral cases may indicate systemic processes. Ninety percent of cases occur in women between the ages of 20-40 years, 80% of cases are unilateral, and 70% of cases are associated with decreased deep tendon reflexes (Adie syndrome). Aberrant reinnervation and upregulation of postsynaptic receptors lead to the clinical presentation of a tonically dilated pupil with reaction to near stimulation but poor reaction to light. Further pharmacologic work-up (see diagnostic procedures) is useful in confirming Horner syndrome and historically was used to localize the lesion.Īdie tonic pupil results from damage to the parasympathetic ciliary ganglion or short ciliary nerves that innervate the sphincter pupillae and ciliary muscle. Postganglionic or third-order neuron lesions include carotid artery dissection, cavernous sinus lesion, otitis media, and head or neck trauma. Preganglionic or second-order neuron lesions may be caused by a Pancoast tumor, mediastinal or thyroid mass, cervical rib, neck trauma, or surgery. Central or first-order lesions are often caused by stroke (may present as lateral medullary syndrome) or demyelinating disease. Anisocoria is greater in the dark due to a defect in the pupillary dilator response secondary to lesions along the sympathetic trunk. Horner’s syndrome (oculosympathetic palsy) is classically described by the triad of ptosis, miosis, and anhidrosis, although clinical presentations may vary. Prostaglandins, opioids, and organophosphate insecticides can constrict pupils as well. ![]() Sympathomimetics, such as adrenaline, clonidine, and phenylephrine, cause mydriasis through their actions at ɑ-1 receptors of the pupillary dilator muscle. The use of pilocarpine, a non-selective muscarinic receptor agonist in the parasympathetic nervous system, may result in a small and poorly reactive pupil. Scopolamine patches, glycopyrrolate antiperspirants, nasal vasoconstrictors, and herbals such as Jimson weed, blue nightshade, and Angel’s trumpet can dilate pupils. Anticholinergics such as atropine, homatropine, tropicamide, scopolamine, and cyclopentolate lead to mydriasis and cycloplegia by inhibiting parasympathetic M3 receptors of the pupillary sphincter and ciliary muscles. Pharmacologic anisocoria can present as mydriasis or miosis following administration of agents that act on the pupillary dilator or sphincter muscles. Causes include physical injury from ocular trauma or surgery, inflammatory conditions such as uveitis, angle closure glaucoma leading to iris occlusion of the trabecular meshwork, or intraocular tumors causing physical distortion of the iris. Mechanical anisocoria results from damage to the iris or its supporting structures. Examples include aniridia, coloboma, and ectopic pupil. Physiologic anisocoria may be intermittent, persistent, or even self-resolving.Ĭongenital anomalies in the structure of the iris may contribute to abnormal pupillary sizes and shapes that present in childhood. Light and near responses are intact, and the degree of anisocoria is typically equal in light and dark. The exact cause is unknown, but it is thought to be due to transient asymmetric supranuclear inhibition of the Edinger-Westphal nucleus that controls the pupillary sphincter. It is a benign condition with a difference in pupil size of less than or equal to 1 mm. Physiologic (also known as simple or essential) anisocoria is the most common cause of unequal pupil sizes, affecting up to 20% of the population. An injury or lesion in either pathway may result in changes in pupil size. Generally, anisocoria is caused by impaired dilation (a sympathetic response) or impaired constriction (a parasympathetic response) of pupils. Thus, thorough clinical evaluation is important for appropriate diagnosis and management of the underlying cause. It is relatively common, and causes vary from benign physiologic anisocoria to potentially life-threatening emergencies. ![]() Anisocoria indicates unequal pupil sizes. |